2135 Charlotte St., Suite 3, Bozeman, MT 59718 Phone: (406) 586-8030 Fax: (406) 586-8036

Blood Test for Concussions

Blood Test for Concussion?

S100B is a serum protein that is thought to aid in the functioning of neurons early in life, and it is present only in the brain. In studies over the past several years, the S100B protein has been found to be transiently increased in the bloodstream after mild TBI (Dash et al, 2010), suggesting that the blood brain barrier can be compromised in traumatic brain injury, including concussion.  It has been evaluated in six clinical trials with over 2000 participants and demonstrated 98% sensitivity in diagnosis of mild TBI. 

The blood–brain barrier (BBB) is a separation of circulating blood from cerebral spinal fluid in the central nervous system (CNS).  It is semi-permeable, allowing some materials to cross, but preventing others from crossing.  The blood–brain barrier protects the brain from many common bacterial infections, antibodies, poisons and certain drugs.

When the S100B protein becomes present in the bloodstream, the body may react to it as a foreign invader and release auto-antibodies to attack it. The antibodies can then leak into the brain through the weakened blood-brain barrier where they are thought to attack brain tissue. In one recent study, four out of 27 football players who had pre- and in-season blood tests showed signs of an autoimmune response to elevated S100B levels.

In the future, testing for the presence of the S100B protein following suspected concussion may be one way to rapidly confirm injury. In 2010, the U.S. Army announced that 34 patients had been accurately diagnosed with traumatic brain injury via a blood test for other proteins (SBDP145 and SBDP120) that seep through the blood-brain barrier after damage. The Army data focused on mild to severe injury, so ongoing S100B studies might help create blood testing technology to detect mild brain trauma quickly and perhaps for as little as $40. S100B blood tests are already used outside of sports, and as a standard procedure in a few emergency rooms in Germany for diagnosing brain trauma.

8 comments (Add your own)

1. Bernuncia wrote:
Jessica,We are back from France and getting very anioxus to share pictures of our wedding. When can we expect them to be posted and when and how will I receive the disc of pictures from you?Thanks again!Carmen Fowler LaBerge843-301-5673

Sun, June 30, 2013 @ 5:26 AM

2. Laure wrote:
I just read your report of David's acidcent . I am so thankful to hear that Heavenly Father was watching out over him with protection of his life. My prayers are for a quick recovery.David is a Noble soul, one of God's favorite sons and a valiant servant in the fight for what is right, good and honorable in our Nation. Thanks be to God for his life, his contributions to truth and the noble principles enshrined in our glorious Constitution. Thanks also to you Nancy for all you do to preserve us from the dregs of the ungodly or ignorant leftists who would subvert everything we hold dear.

Mon, July 1, 2013 @ 4:50 PM

3. buy prednisone tablets without prescription wrote:
I'm not easily impressed. . . but that's impressing me! :)

Thu, August 29, 2013 @ 6:40 PM

4. typical car insurance rates wrote:
You have the monopoly on useful information-aren't monopolies illegal? ;)

Fri, October 18, 2013 @ 8:54 AM

5. affordable car insurance wrote:
Wow! Great to find a post with such a clear message!

Sat, October 26, 2013 @ 11:43 AM

6. htbwwvwz wrote:
idsrnod

Thu, May 8, 2014 @ 9:57 PM

7. Alinnnaaa wrote:

Sat, January 14, 2017 @ 1:26 PM

8. MatthewBrone wrote:
Hunderte plastische Eingriffe wie Brustvergrößerung, Fettabsaugung oder Facelift werden von uns pro Jahr durchgeführt.
Auf unseren Webseiten finden Sie alle wichtigen Informationen wie Fotos, Preise, Bilder, Kosten und Finanzierung über Ihre Wunschoperation.

Schönheitschirurgische Eingriffe in der modernsten Schönheitsklinik Europas müssen nicht zwangsläufig teuer sein. Billig und teuer sind ohnehin dependent on Begriffe bei Facelift, Fettabsaugung und Brustvergrößerung. Gespart werden kann überall, doch bedenken Sie, im medizinischen Bereich geht dies sicher auf Kosten ihrer Gesundheit.
facelift
facelift

Sat, January 21, 2017 @ 1:34 PM

Add a New Comment


code
 

Comment Guidelines: No HTML is allowed. Off-topic or inappropriate comments will be edited or deleted. Thanks.